The 120-mile-long Florida Keys island chain is linked to mainland Florida by U.S. Route 1, the Overseas Highway. Driving down the Keys from Miami takes about 3.5 hours and there are some beaches and a couple of state parks along the way.
If you’re driving from Miami International Airport, take LeJeune Road south to 836 West. Take the Florida Turnpike south toward Key West. The Turnpike ends at US 1 in Florida City. Follow U.S. 1 south as far as it goes and you will be in Key West.
From Ft. Lauderdale-Hollywood International Airport, exit the airport and follow the signs for 595 West. Take 595 to the Florida Turnpike and follow the signs for the Florida Keys and Key West.
From the north, take the Florida Turnpike south and follow the signs for Homestead and Key West. The Florida Turnpike ends at US 1 in Florida City.Follow U.S. 1 south into the Florida Keys.
From Florida’s west coast, take 1-75 Alligator Alley east to the Miami exit, and south to the Turnpike Extension.